OPPORTUNITIES AND CHALLENGES OF DELIVERING DIGITAL CLINICAL TRIALS: LESSONS LEARNED FROM A RANDOMISED CONTROLLED TRIAL OF AN ONLINE BEHAVIOURAL INTERVENTION FOR CHILDREN AND YOUNG PEOPLE

Abstract Background Despite being the gold standard of research to determine effectiveness, randomised controlled trials (RCTs) often struggle with participant recruitment, engagement and retention.These issues may be exacerbated when recruiting vulnerable populations, such as participants with mental health issues.We aimed to update understanding

IntroductionThe formation and functioning of neural networks hinge Two Drawer Nightstand critically on the balance between structurally homologous areas in the hemispheres.This balance, reflecting their physiological relationship, is fundamental for learning processes.In our study, we explore this functional homology in the resting state, employing

A new image enhancement algorithm employing guided filtering is proposed in this work for enhancement of solar images and videos, so that users can easily figure out important fine structures imbedded in the recorded images/movies for solar observation.The proposed algorithm can Ornaments efficiently remove image noises, including Gaussian and impu

The cerebellum plays a crucial role in the regulation of locomotion, but how movement is represented at the synaptic level is not known.Here, we use in vivo Two Drawer Nightstand patch-clamp recordings to show that locomotion can be directly read out from mossy fiber synaptic input and spike output in single granule cells.The increase in granule ce